The Evolution of Bacteria on a “Mega-Plate” Petri Dish (Kishony Lab)

> Why do you think the strongest of the strong bacteria are found in hospitals? I presume you mean strong against antibiotics and sterilisation. The evolved bacteria are likely weaker along other dimensions (that are less important for survival in a hospital setting). Some evolution is compromises, improving X has cost Y. Aside: the mega-plate video is an unbelievably good demonstration of bacterial evolution: ▶ this video especially note the tree at the end showing how many different mutations evolved.

This is an amazing video[1] from Harvard Medical School released couple of days ago showing evolution of bacteria that evolve in 10 days to become resistant to antibiotics. [1] ▶ this video

Strengthens your immune system. Without exposure (playing in mud, touching other people), we are only weaker. Bio life is really complicated. Sterilization works well only to a certain degree, before becoming damaging, e.g. causing resistance. Somewhat related, here is an interesting visualization of bacteria developing resistance to antibiotics. ▶ this video

Harvard medical school did a similar experiment on fast evolution of bacterial resistance to antibiotics on a petri-dish. It also clearly shows the lineage of evolution. Very interesting. ▶ this video

For those that would like to visualise how the bacteria vs anitbiotics evolve in an experiment over 11 days, have a look at this video from Harvard: ▶ this video

The video shows mutations in real time as bacteria grow or fail to grow in various places. ▶ this video It's more a demonstration than experiment, but visually it's just really striking.

>there's no "be a better/stronger cancer and spread more effectively to more hosts" No, but there is "be a better/stronger cancer cell and don't succumb to whatever therapy is killing its neighboring cells." It's exactly akin to how dosing isolated populations of bacteria with antibiotics selects for individual cells that are resistant, which then multiply and dominate [0], just like a tumor. [0] ▶ this video

Aging is one side effect of a major internal system that counteracts cancers. Most of our cells are preprogrammed to die after a certain number of replications. This is one of many systems that counteract normal genetic mutations - which can cause cancers and other side effects. By definition a cancer has to reproduce and one way of defeating cancers is for cells to die (or be killed) once they reach a number of cell reproductions. Think of a binary tree where the tree depth is the number of cell reproductions, and telomere length controls tree depth. Each time a cell reproduces it risks mutations. Stem cells are the progenitor branches, and stem cells maintain “cleaner” copies of DNA, which then become normal cells. Normal cells then reproduce a number of times before they kill themselves. We have evolved this system because it balances the shorter term harms of cancer (high cost preventing reproduction), and senescence (lower cost after reproduction). There can be no “cure” for cancer, or aging. The cure would for cancer would require some way to either cause perfect cell reproduction, or to remove (or correct) all cells with imperfect reproductions. The “cure” for aging would require a cure for cancer. If I were to invest in something myself, it would be brain transplant, since brain cancers are rare, and dealing with organ rejection seems doable, and the issue of nerve reconnection seems solvable. The main problem is finding spare bodies, which can be unethically solved f

>BTW, the "serial dilution" method name sounds to me like what is illustrated by this famous video: ▶ this video Great video, ( if it's not fictitious)

Really I feel like this has been a hot topic for at least 15 years.. for example 5 years ago this ▶ this video was on hacker news and got a lot of discussion as I recall… Ok maybe you are right my search yielded few posts that got any traction - so maybe it was just me sharing with people I know!

>What are the tests? Tests == adaptation to the environment E.g. short 2 minute video showing how bacteria evolves with random mutations to produce resistance to antibiotics: ▶ this video Likewise at a macro scale, if Earth's atmosphere becomes inhospitable because of global nuclear war or a big asteroid collision, then the new "test for life" is adapting to the radioactive dust cloud. Keep mutating across generations until survivors can thrive.

Honest question here, do vaccines actually reduce the chance for covid to mutate? Spitballing, I would expect a vaccine to decrease the number of total mutations that can occur but also simultaneously increase the selective pressure on the virus, increasing the chance that any mutations that improve the virus’ ability to resist the vaccine become dominant. To make an analogy, does spraying every surface in a hospital with an antibacterial solution result in no bacteria or just make it more likely to see resistant bacteria? I’d guess it’s a function of how potent the solution was and how well every last surface was coated. If you start with a 10% solution, don’t achieve full coverage and keep ramping up slowly perhaps we’ll just see something like this: ▶ this video Agree with the rest of your post though.